<track id="llhjh"></track>

        <track id="llhjh"></track>

          <pre id="llhjh"></pre>

          <big id="llhjh"></big>

            來寶網Logo

            熱門詞:生物顯微鏡 水質分析儀 微波消解 熒光定量PCR 電化學工作站 生物安全柜

            AED
            現在位置首頁>實驗室原料試劑耗材>抗體>細胞凋亡抗體>ASK1 現貨抗體 先用后付 國內備貨
            ASK1  現貨抗體  先用后付 國內備貨
            ASK1  現貨抗體  先用后付 國內備貨
            • ASK1  現貨抗體  先用后付 國內備貨

            ASK1 現貨抗體 先用后付 國內備貨

            產品報價:220元

            更新時間:2013/10/29 14:40:19

            地:美國

            牌:ABclonal

            號:A0283

            廠商性質: 生產型,服務型,

            公司名稱: 上海英基生物科技有限公司

            產品關鍵詞:

            913
            訪問人數
            0
            累計評論


            吳從杰 : (18611693594) (010-82864773)

            (聯系我時,請說明是在來寶網上看到的,謝謝?。?/b>


            ASK1 Polyclonal Antibody­

            ASK1 A0283.pdf

            Catalog No: A0283

            Species: Rabbit

            Gene ID: 4217

            Isotype: IgG

            Swiss Prot: Q99683

            Purity: Affinity purification

            Applications: WB  

            Cross-Reactivity: H   M   R  

            Size

            Pr­ice (USD)

            Availability

            100ug

            220

            Ship in 5 business days

            Adding to the cart

            200ug

            380

            Ship in 5 business days

            Adding to the cart

            ????????

            Alt. Names

            MAP3K5;ASK1;MAPKKK5;MEKK5 ;


            Recommended Dilutions

            WB: 1:500-1:2000


            Products data

                                   

            Western blot analysis of extracts of K562 cells, using ASK1 antibody.


            Immunogen

            Recombinant protein of human ASK1


            Storage

            Store at -20oC or -80oC. Avoid freeze / thaw cycles.

            Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


            Background

            Apoptosis signal-regulating kinase 1 (ASK1), a MAP kinase kinase kinase, plays essential roles in stress-induced apoptosis (1,2). ASK1 is activated in response to a variety of stress-related stimuli through distinct mechanisms and activates MKK4 and MKK3, which in turn activate JNK and p38 (3). Overexpression of ASK1 activates JNK and p38 and induces apoptosis in several cell types through signals involving the mitochondrial cell death pathway. Embryonic fibroblasts or primary neurons derived from ASK1-/- mice are resistant to stress-induced JNK and p38 activation and cell death (4,5). Phosphorylation at Ser967 is essential for ASK1 association with 14-3-3 protein and suppression of cell death (6). Oxidative stress induces dephosphorylation of Ser967 and phosphorylation of Thr845 in the activation loop of ASK1, and both are correlated with ASK1 activity and ASK1-dependent apoptosis (7,8). On the other hand, Akt phosphorylates ASK1 at Ser83, which attenuates ASK1 activity and promotes cell survival (9).

            1.      Ichijo, H. et al. (1997) Science 275, 90-94.

            2.      Wang, X.S. et al. (1996) J. Biol. Chem. 271, 31607-31611.

            3.      Matsuzawa, A. and Ichijo, H. (2001) J. Biochem. (Tokyo) 130, 1-8.

            4.      Tobiume, K. et al. (2001) EMBO Rep. 2, 222-228.

            5.      Nishitoh, H. et al. (2002) Genes Dev. 16, 1345-1355.

            6.      Zhang, L. et al. (1999) Proc. Natl. Acad. Sci. USA 96, 8511-8515.

            7.      Tobiume, K. et al. (2002) J. Cell. Physiol. 191, 95-104.

            8.      Goldman, E.H. et al. (2004) J. Biol. Chem. in press, .

            9.      Kim, A.H. et al. (2001) Mol. Cell. Biol. 21, 893-901.



            16青少年男生穿透明内裤照片

                <track id="llhjh"></track>

                  <track id="llhjh"></track>

                    <pre id="llhjh"></pre>

                    <big id="llhjh"></big>