<track id="llhjh"></track>

        <track id="llhjh"></track>

          <pre id="llhjh"></pre>

          <big id="llhjh"></big>


            熱門詞:生物顯微鏡 水質分析儀 微波消解 熒光定量PCR 電化學工作站 生物安全柜

            現在位置首頁>實驗室原料試劑耗材>抗體>細胞凋亡抗體>樂博現貨供應美國ProSci凋亡相關--Noxa antibody
            樂博現貨供應美國ProSci凋亡相關--Noxa antibody
            樂博現貨供應美國ProSci凋亡相關--Noxa antibody
            • 樂博現貨供應美國ProSci凋亡相關--Noxa antibody

            樂博現貨供應美國ProSci凋亡相關--Noxa antibody


            更新時間:2012/7/18 15:46:20




            廠商性質: 生產型,貿易型,服務型,

            公司名稱: 北京樂博生物科技有限公司



            劉小姐 : (13621283223) (4006130504)


            北京樂博生物科技有限公司是美國ProSci授權一級代理商,供應其全線產品涵蓋了細胞凋亡、信號傳導、腫瘤、免疫、細胞生物、神經生物和傳染病等領域。產品應用于ELISA、WB、IHC、FACS等,為您的實驗提供多樣的檢測手段,產品應用文獻發表在PNAS、Cell research、Blood……使用廣泛。


            Primary Antibodies

            Noxa Antibody


            Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified , which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9 . Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53 (1-3). Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development (4).


            Additional Names

            Noxa, PMA-induced protein 1, PMAIP1, APR

            Noxa Antibody


            Left: Western blot analysis of Noxa in human stomach tissue lysate with Noxa antibody at (A) 0.5, (B) 1 and (C) 2 μg/ml.

            Below: Immunohistochemistry of Noxa in human stomach tissue with Noxa antibody at 1 μg/ml.

            Other Product Images


            Noxa antibody was raised against a synthetic peptide corresponding to 17 amino acids at the amino terminus of mouse Noxa.


            Immunoaffinity chromatography purified IgG

            Clonality / Clone

            This is a polyclonal antibody.


            Noxa antibody was raised in rabbit.

            Please use anti-rabbit secondary antibodies.


            Human Noxa Peptide (Cat. No. 2437P)


            Noxa antibody can be used for detection of Noxa by Western blot at 0.5 to 1 μg/ml. Human stomach cell lysate can be used as a positive control. Noxa antibody is human, mouse and rat reactive. This product is for research use only.

            Tested Application

            E, WB, IHC


            Antibody is supplied in PBS containing 0.02% sodium azide.

            Blocking Peptide

            Cat. No. 2437P - Noxa Peptide


            Noxa antibody can be stored at 4?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

            Positive Control

            1. Cat. No. 1319 - Human Stomach Tissue Lysate

            Species Reactivity

            H, M, R

            Protein GI Number


            Protein Accession Number


            Short Description

            A p53 target gene

            This product belongs to the following categories:

            • Antibodies
            • Polyclonal Antibodies
            • Apoptosis Antibodies
            • Cancer Antibodies

            Related Products

            • Bim Antibody
              (Catalog No. 2065).
            • Bmf Antibody
              (Catalog No. 3031).
            • Chk2 Antibody
              (Catalog No. 2391).
            • Noxa Peptide
              (Catalog No. 2437P).
            • p53DINP1 Antibody
              (Catalog No. 3045).
            • p53R2 Antibody
              (Catalog No. 2383).
            • PUMA Antibody
              (Catalog No. 3041).
            • Stomach Lysate
              (Catalog No. 1319).
            • Stomach Tissue Slide (Normal)
              (Catalog No. 10-801).


            1. Oda E, Ohki R, Murasawa H, et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 2000; 288:1053-8.
            2. Nakano K and Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 2001; 7:683-94.
            3. Yu J, Zhang L, Hwang PM, et al. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 2001; 7:673-82.
            4. Eferl R, Ricci R, Kenner L, et al. Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Cell 2003; 112:181-92.





                <track id="llhjh"></track>

                  <track id="llhjh"></track>

                    <pre id="llhjh"></pre>

                    <big id="llhjh"></big>