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            現在位置首頁>實驗室原料試劑耗材>抗體>細胞凋亡抗體>樂博現貨供應美國ProSci凋亡相關--Caspase-12 (NT) antibody
            樂博現貨供應美國ProSci凋亡相關--Caspase-12 (NT) antibody
            樂博現貨供應美國ProSci凋亡相關--Caspase-12 (NT) antibody
            • 樂博現貨供應美國ProSci凋亡相關--Caspase-12 (NT) antibody

            樂博現貨供應美國ProSci凋亡相關--Caspase-12 (NT) antibody

            產品報價:2950元

            更新時間:2012/7/18 15:47:33

            地:北京

            牌:ProSci

            號:2325

            廠商性質: 生產型,貿易型,服務型,

            公司名稱: 北京樂博生物科技有限公司

            產品關鍵詞:

            338
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            劉小姐 : (13621283223) (4006130504)

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            北京樂博生物科技有限公司是美國ProSci授權一級代理商,供應其全線產品涵蓋了細胞凋亡、信號傳導、腫瘤、免疫、細胞生物、神經生物和傳染病等領域。產品應用于ELISA、WB、IHC、FACS等,為您的實驗提供多樣的檢測手段,產品應用文獻發表在PNAS、Cell research、Blood……使用廣泛。

            抗體信息如下:

            Primary Antibodies

            Caspase-12 Antibody

            Background

            Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved (1,2). Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including g-secretase presenilin and b-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-b. Caspase-12 is ubiquitously expressed in mouse tissues (1).

             

            Additional Names

            Caspase-12 (NT), Casp-12

            Caspase-12 Antibody

            Description

            Left: Western blot analysis of caspase-12 in human (A) and mouse (B) spleen tissue lysates with caspase-12 antibody at 1 μg/ml.

            Below: Immunohistochemistry of caspase-12 in human heart tissue with caspase-12 antibody at 10 μg/ml.
             

            Other Product Images

            Source

            Caspase-12 antibody was raised against a peptide corresponding to amino acids 2 to 17 of murine caspase-12.

            Purification

            Affinity chromatography purified via peptide column

            Clonality / Clone

            This is a polyclonal antibody.

            Host

            Caspase-12 antibody was raised in rabbit.

            Please use anti-rabbit secondary antibodies.

            Immunogen

            Mouse Caspase-12 (N-Terminus) Peptide (Cat. No. 2325P)

            Application

            Caspase-12 antibody can be used for detection of caspase-12 by Western blot at 0.5 to 1 μg/ml.

            Tested Application

            E, WB, IHC

            Buffer

            Antibody is supplied in PBS containing 0.02% sodium azide.

            Blocking Peptide

            Cat. No. 2325P - Caspase-12 Peptide

            Storage

            Caspase-12 antibody can be stored at 4?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

            Positive Control

            1. Cat. No. 1406 - Mouse Spleen Tissue Lysate
            2. Cat. No. 1301 - Human Heart Tissue Lysate
            3. Cat. No. 1306 - Human Spleen Tissue Lysate

            Species Reactivity

            H, M, R

            Protein GI Number

            2094806

            Protein Accession Number

            CAA73532

            Short Description

            (NT) A new caspase

            This product belongs to the following categories:

            • Antibodies
            • Polyclonal Antibodies
            • Apoptosis Antibodies
            • Cancer Antibodies

            Related Products

            • Caspase-12 Peptide
              (Catalog No. 2325P).
            • Heart Lysate
              (Catalog No. 1301).
            • Heart Tissue Slide (Normal)
              (Catalog No. 10-501).
            • Multiple Species Tissue Array - Spleen Tissue
              (Catalog No. 10-900-MSTA).
            • Spleen Lysate
              (Catalog No. 1306).
            • Spleen Lysate
              (Catalog No. 1406).
            • Spleen Tissue Slide (Normal)
              (Catalog No. 10-901).

            References

            1. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β. Nature 2000;403:98-103.
            2. Mehmet H. Caspases find a new place to hide. Nature 2000;403:29-30
            3. Van de Craen M, Vandenabeele P, Declercq W, Van den Brande I, Van Loo G, Molemans F, Schotte P, Van Criekinge W, Beyaert R, Fiers W. Characterization of seven murine caspase family members. FEBS Lett 1997;403:61-9 (WD1000)

             

            更多現貨抗體歡迎咨詢樂博生物:010-59564854



             



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