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            樂博現貨供應美國ProSci凋亡相關--FLIP (CT) antibody
            樂博現貨供應美國ProSci凋亡相關--FLIP (CT) antibody
            • 樂博現貨供應美國ProSci凋亡相關--FLIP (CT) antibody

            樂博現貨供應美國ProSci凋亡相關--FLIP (CT) antibody

            產品報價:2950元

            更新時間:2012/7/18 15:51:57

            地:北京

            牌:ProSci

            號:1161

            廠商性質: 生產型,貿易型,服務型,

            公司名稱: 北京樂博生物科技有限公司

            產品關鍵詞:

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            劉小姐 : (13621283223) (4006130504)

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            抗體信息如下:

            Primary Antibodies

            FLIP Antibody

            Background

            Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively1,2. The human FLIP was also cloned by several labs independently and termed Casper , I-FLICE, FLAME-1, CASH and CLARP3-7. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of c-FLIPs have been identified and termed FLIPα, β, γ, and δ, respectively (8).

             

            Additional Names

            FLIP (CT), I-FLICE

            FLIP Antibody

            Description

            Left: Western blot analysis of FLIP in HeLa (H), Jurkat (J), and K562 (K) whole cell lysate with FLIP antibody at 1:1000 dilution.

            Below: Immunocytochemistry of FLIP in Jurkat cells with FLIP antibody at 10 μg/ml.
             

            Other Product Images

            Source

            FLIP antibody was raised against a peptide corresponding to amino acids near the C-terminus of human FLIPaFLIPl form.

            Purification

            Antibody is DEAE purified

            Clonality / Clone

            This is a polyclonal antibody.

            Host

            FLIP antibody was raised in rabbit.

            Please use anti-rabbit secondary antibodies.

            Immunogen

            Bacteria FLIP (C-Terminus) Peptide (Cat. No. 1161P)

            Application

            Flip antibody can be used for detection of FLIP by Western blot at 1:500 to 1:2000 dilution. A 55 kDa band can be detected. antibody recognizes the FLIPa only.

            Tested Application

            E, WB, ICC

            Buffer

            Antibody is supplied in PBS containing 0.02% sodium azide.

            Blocking Peptide

            Cat. No. 1161P - FLIP Peptide

            Storage

            FLIP antibody can be stored at 4?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

            Positive Control

            1. Cat. No. 1201 - HeLa Cell Lysate

            Species Reactivity

            H, M, R

            Protein GI Number

            2253679

            Protein Accession Number

            AAC51622

            Short Description

            (CT) FLICE inhibitory protein

            This product belongs to the following categories:

            • Antibodies
            • Polyclonal Antibodies
            • Apoptosis Antibodies

            Related Products

            • Caspase-10 Antibody
              (Catalog No. 1128).
            • Caspase-8 Antibody
              (Catalog No. 3475).
            • FLIP Antibody
              (Catalog No. 1159).
            • FLIP Peptide
              (Catalog No. 1161P).
            • HeLa Cell Slide
              (Catalog No. 17-001).
            • HeLa Lysate
              (Catalog No. 1201).

            References

            1. Thome M, Schneider P, Hofmann K, et al. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 1997;386:517-521
            2. Irmler M, Thome M, Hahne M, et al. Inhibition of death receptor signals by cellular FLIP. Nature 1997;388:190-195
            3. Shu HB, Halpin DR , Goeddel DV. Casper is a FADD- and caspase-related inducer of apoptosis. Immunity 1997;6:751-763
            4. Hu S, Vincenz C, Ni J, Gentz R, Dixit VM. I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis. J Biol Chem 1997;272:17255-17257


             

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