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                    超高速視頻級原子力顯微鏡HS-AFM
                
            
            
            
            
            
                
            
                    
                    
                    
                    
                    
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            超高速視頻級原子力顯微鏡HS-AFM
            
                
            
                
            
                    
            
                        價    格：3800000
            
                    
            
                        產    地：日本更新時間：2023/3/19 19:56:15
                    
            
                    
            
                        品    牌：RIBM型    號：HS-AFM
            
                    
            
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            超高速視頻級原子力顯微鏡HS-AFM（High-Speed Atomic Force Microscope，HS-AFM）由日本 Kanazawa 大學 Prof. Ando 教授團隊研發，日本RIBM公司商業化的產品，可以達到視頻級成像的商業化原子力顯微鏡。HS-AFM突破了傳統原子力顯微鏡“掃描成像速慢”的限制，能夠在液體環境下超快速動態成像，分辨率為納米水平。

            超高速視頻級原子力顯微鏡HS-AFM（High-Speed Atomic Force Microscope，HS-AFM）由日本 Kanazawa 大學 Prof. Ando 教授團隊研發，日本RIBM公司（生體分子計測研究所株式會社，Research Institute of Biomolecule Metrology Co., Ltd）商業化的產品，可以達到視頻級成像的商業化原子力顯微鏡。HS-AFM突破了傳統原子力顯微鏡“掃描成像速慢”的限制，能夠在液體環境下Chao快速動態成像，分辨率為納米水平。樣品Wu需特殊固定，不影響生物分子的活性，尤其適用于生物大分子互作動態觀測。超高速視頻級原子力顯微鏡HS-AFM主要有兩種型號，SS-NEX樣品掃描（Sample-Scanning HS-AFM）以及PS-NEX探針掃描（Probe-Scanning HS-AFM）。推出至今，全有100多位用戶，發表 SCI 文章 300 余篇，包括Science, Nature, Cell 等雜志。
            ?
            相較于市場上的原子力顯微鏡成像設備，HS-AFM突破了 “掃描成像速慢”的限制，掃描速度高可達 20 frame/s，并且有 4 種掃描臺可供選擇。樣品Wu需特殊固定染色，不影響生物分子的活性，尤其適用于生物大分子互作動態觀測。液體環境下直接檢測，超快速動態成像，分辨率為納米水平。探針小，適用于生物樣品；懸臂探針共振頻率高，彈簧系數小，避免了對生物樣品等的損傷。懸臂探針可自動漂移校準，適用于長時間觀測。采用動態PID控制，高速掃描時仍可獲得清晰的圖像。XY軸分辨率2nm；Z軸分辨率0.5nm。
            HS-AFM 擁有超高掃描速率與原子級別分辨率，而且具有操作的簡易性，使得對單分子動態過程的捕捉變得十分方便，為科研工作者研所和理解生物物理、生物化學、分子生物學、病毒學以及生物醫學等領域的單分子動態過程提供了一款強大的工具。
            新的HS-AFM采用了新的高頻微懸臂架構，Geng低噪音、Geng高穩定性的2控制器，高速掃描器，緩沖防震設計，主動阻尼，動態PID，驅動算法You 化，多種Qian沿技術，可以實現在超高速下獲取高分辨的生物樣品信息。新系統整合了基于工作流程的操作軟件，直觀的用戶界面與流程化、自動化的設置使得研究人員可以專注于實驗設計，不需要復雜的操作和條件設置，快速獲取數據，加速研究的產出。


            
                
            
                
                
            
                
                
            
                    
            
                        
            
                            產品參數
            
                    
            
                    
            
                        
            超高速視頻級原子力顯微鏡HS-AFM（High-Speed Atomic Force Microscope，HS-AFM）由日本 Kanazawa 大學 Prof. Ando 教授團隊研發，日本RIBM公司商業化的產品，可以達到視頻級成像的商業化原子力顯微鏡。HS-AFM突破了傳統原子力顯微鏡“掃描成像速慢”的限制，能夠在液體環境下超快速動態成像，分辨率為納米水平。

            ★? ?高頻微懸臂
            彈性系數: ? 0.1 N/m ??
            曲率半徑: ?<10 nm　
            共振頻率: ? 400-600kHz in liquid
            ★? ?高速掃描臺
            20 frames/s. ? (Standard scanner)
            ★? ?緩沖防震+主動阻尼+動態PID+算法You 化
            緩沖防震
            主動阻尼
            動態PID控制：可自動改變反饋增益，HS-AFM在高速掃描條件下仍可獲得清晰的圖像
            探針自動漂移校準，適用于長時間樣品觀測


            
                
            
                
                
            
                
                
            
                    
            
                        
            
                            產品介紹
            
                    
            
                    
            
                        
            超高速視頻級原子力顯微鏡HS-AFM（High-Speed Atomic Force Microscope，HS-AFM）由日本 Kanazawa 大學 Prof. Ando 教授團隊研發，日本RIBM公司商業化的產品，可以達到視頻級成像的商業化原子力顯微鏡。HS-AFM突破了傳統原子力顯微鏡“掃描成像速慢”的限制，能夠在液體環境下超快速動態成像，分辨率為納米水平。

            原子力顯微鏡（Atomic Force Microscope，AFM），一種可用來研究包括絕緣體在內的固體材料表面結構的分析儀器。它通過檢測待測樣品表面和一個微型力敏感元件之間的極微弱的原子間相互作用力來研究物質的表面結構及性質。將一對微弱力極端敏感的微懸臂一端固定，另一端的微小針尖接近樣品，這時它將與其相互作用，作用力將使得微懸臂發生形變或運動狀態發生變化。掃描樣品時，利用傳感器檢測這些變化，就可獲得作用力分布信息，從而以納米級分辨率獲得表面形貌結構信息及表面粗糙度信息。原子力顯微鏡可以測量材料物理性質、力學性能、磁學性能、熱學性能、電學性能等方面的一些特征信息，但在掃描成像速度上一直存在局限性，太慢的掃描速度導致原子力顯微鏡無法捕捉到分子間的相互作用過程和一些快速的分子動態變化。
            ?

            日本RIBM公司的超高速視頻級原子力顯微鏡HS-AFM的的應用領域：
            ?
            從單分子到單細胞，都可直接觀測
            ?
            ?
            1、肌動蛋白
            ?
            2、CRISPR-Cas9
            ?
            ?
            3、膜聯蛋白
            ?
            ?
            4、IgG
            ?
            ?
            5、活細胞
            ?
            ?
            6、細菌視紫紅質
            ?
            ?
            7、DNA納米結構
            ?
            ?
            8、仿生聚合物
            ?
            ?
            日本RIBM公司的超高速視頻級原子力顯微鏡HS-AFM的視頻案例
            ?
            1：IgG
            在溶液中觀察到抗體(IgG)。
            IgG呈"Y"形，兩個Fab區區分清晰。
            由于錨定能力較弱，IgG保持其抗原結合能力。
            ?
            ?
            ?
            2：Plasmid DNA
            傳統AFM在沒有強錨定的情況下，DNA分子圖像出現擺動。
            然而，強錨定可能會削弱真實的結構和行為。
            HS-AFM能清晰顯示質粒的結構和運動，無強錨定。
            ?
            ?
            ?
            3：DNA內切酶的消化：DNase I
            DNA酶I是一種隨機消化DNA的核酸內切酶。視頻中的箭頭表示DNase I消化DNA的部分。
            請參考從DNA末端消化的核酸外切酶Bal31的視頻。
            ?
            ?
            ?
            4：DNA外切酶消化：Bal31
            Bal31是一種從DNA鏈末端消化DNA的核酸外切酶。
            視頻顯示Bal31的活性沿著DNA移動，并逐漸從DNA鏈的末端消化。
            DNA分子被完全消化，但環狀DNA未被消化。高光點是Bal31分子，它們與DNA的不同位置結合。
            ?
            ?
            ?
            5：DNA聚合酶的DNA延伸：Phi29
            雙鏈DNA(黃色)隨著時間的推移而拉長。單鏈λDNA作為模具固定在基板上。
            由于從隨機六聚體引物(Red)結合到λDNA模體，phi29聚合酶(Black)以dNTP為底物合成互補DNA。
            ?
            ?
            ?
            6：鏈親和素2D晶體中的點缺陷
            成功地觀察到點缺陷在晶體中的擴散。
            從圖像上看，兩個單空位缺陷的軌跡跟蹤相對于晶格的兩個軸是明顯的各向異性的。
            ?
            ?
            ?
            ?
            日本RIBM公司的超高速視頻級原子力顯微鏡HS-AFM的文獻列表
            ?
            TitleJournal
            Biophysical reviews top five: atomic force microscopy in biophysicsBiophysical Reviews
            Reconstruction of Three-Dimensional Conformations of Bacterial
            ClpB from High-Speed Atomic-Force-Microscopy Images            		Frontiers in Molecular
            Biosciences
            A facile combinatorial approach to construct a ratiometric fluorescent
            sensor: application for the real-time sensing of cellular pH changes            		Chemical Science
            DNA Nanotechnology to Disclose Molecular Events at the Nanoscale
            and Mesoscale Levels            		Springer Nature
            Quantitative description of a contractile macromolecular machineScience Advances
            Dynamic Assembly/Disassembly of Staphylococcus aureus FtsZ
            Visualized by High-Speed Atomic Force Microscopy            		International Journal of
            Molecular Sciences 2021, Vol. 22, Page 1697
            Localization atomic force microscopyNature 2021 594:7863
            Movements of mycoplasma mobile gliding machinery detected by
            high-speed atomic force microscopy            		mBio
            An ultra-wide scanner for large-area high-speed atomic force
            microscopy with megapixel resolution            		Scientific Reports 2021 11:1
            A molecularly engineered, broad-spectrum anti-coronavirus lectin
            inhibits SARS-CoV-2 and MERS-CoV infection in vivo            		Research Square
            Influenza virus ribonucleoprotein complex formation occurs in the
            nucleolus            		bioRxiv
            Tardigrade Secretory-Abundant Heat-Soluble Protein Has a Flexible
            β-Barrel?Structure?in?Solution?and?Keeps?This?Structure?in
            Dehydration            		Journal of Physical Chemistry B
            Ultrastructure of influenza virus ribonucleoprotein complexes during
            viral RNA synthesis            		Communications Biology on
            A facile combinatorial approach to construct a ratiometric fluorescent
            sensor: application for the real-time sensing of cellular pH changes            		Chemical Science
            Deformation of microtubules regulates translocation dynamics of
            kinesin            		Science Advances
            Unraveling the host-selective toxic interaction of cassiicolin with lipid
            membranes and its cytotoxicity            		bioRxiv
            Nanostructure and thermoresponsiveness of poly( N -isopropyl
            methacrylamide)-based hydrogel microspheres prepared via aqueous free radical precipitation polymerization            		RSC Advances
            JRAB/MICAL-L2?undergoes?liquid–liquid?phase?separation?to?form
            tubular recycling endosomes            		Communications Biology 2021
            4:1
            Correlation of membrane protein conformational and functional
            dynamics            		Nature Communications 2021
            12:1
            Non-close-packed arrangement of soft elastomer microspheres on
            solid substrates            		RSC Advances
            Folding?RNA–Protein?Complex?into?Designed?NanostructuresMethods in Molecular Biology
            A glutamine sensor that directly activates TORC1Communications Biology 2021
            4:1
            Architecture of zero-latency ultrafast amplitude detector for high-
            speed atomic force microscopy            		Applied Physics Letters
            Correlative AFM and fluorescence imaging demonstrate nanoscale
            membrane remodeling and ring-like and tubular structure formation by septins            		Nanoscale
            Desiccation-induced fibrous condensation of CAHS protein from an
            anhydrobiotic tardigrade            		bioRxiv
            Construction?of?ferritin?hydrogels?utilizing?subunit–subunit
            interactions            		PLOS ONE
            Monomeric?α-synuclein?(αS)?inhibits?amyloidogenesis?of?human
            prion?protein?(hPrP)?by?forming?a?stable?αS-hPrP?hetero-dimer.            		Prion
            Influence of protein adsorption on aggregation in prefilled syringesJournal of Pharmaceutical
            Sciences
            Dynamic mechanisms of CRISPR interference by Escherichia coli
            CRISPR-Cas3            		bioRxiv
            An RNA Triangle with Six Ribozyme Units Can Promote a Trans-
            Splicing Reaction through Trimerization of Unit Ribozyme Dimers            		Applied Sciences
            Faster high-speed atomic force microscopy for imaging of
            biomolecular processes Review of Scientific Instruments ARTICLE scitation.org/journal/rsi Faster high-speed atomic force microscopy for imaging of biomolecular processes            		Rev. Sci. Instrum
            Title: Identification of lectin receptors for conserved SARS-CoV-2
            glycosylation sites            		bioRxiv
            Structural and dynamics analysis of intrinsically disordered proteins
            by high-speed atomic force microscopy            		Nature Nanotechnology
            Millisecond Conformational Dynamics of Skeletal Myosin II Power
            Stroke Studied by High-Speed Atomic Force Microscopy            		ACS Nano
            High-Speed Atomic Force Microscopy Reveals Spatiotemporal
            Dynamics of Histone Protein H2A Involution by DNA Inchworming            		The Journal of Physical
            Chemistry Letters
            Nanostructures, Thermoresponsiveness, and Assembly Mechanism
            of Hydrogel Microspheres during Aqueous Free-Radical Precipitation Polymerization            		Langmuir
            Chained structure of dimeric F 1-like ATPase in Mycoplasma mobile
            gliding machinery 4            		bioRxiv
            Lipid Membrane Interaction of Peptide/DNA Complexes Designed for
            Gene Delivery            		Langmuir
            High-Speed Atomic Force Microscopy to Study Myosin MotilityAdvances in Experimental
            Medicine and Biology
            Single-molecule level dynamic observation of disassembly of the
            apo-ferritin cage in solution            		Physical Chemistry Chemical
            Physics
            Atomic Force Microscopy of Biomembranes : A Tool for Studying the
            Dynamic Behavior of Membrane Proteins            		New Techniques for Studying
            Biomembranes
            Adenosine leakage from perforin-burst extracellular vesicles inhibits
            perforin secretion by cytotoxic T-lymphocytes            		PLOS ONE
            High-Speed Atomic Force Microscopy Reveals the Structural
            Dynamics?of?the?Amyloid-β?and?Amylin?Aggregation?Pathways            		International Journal of
            Molecular Sciences 2020, Vol. 21, Page 4287
            Molecular mechanism of the recognition of bacterially cleaved
            immunoglobulin by the immune regulatory receptor LILRA2            		Journal of Biological Chemistry
            Biological physics by high-speed atomic force microscopyPhilosophical Transactions of
            the Royal Society A: Mathematical, Physical and Engineering Sciences
            Viral RNA recognition by LGP2 and MDA5, and activation of signaling
            through step-by-step conformational changes            		Nucleic Acids Research
            Key Nucleation Stages and Associated Molecular Determinants and
            Processes in pH-Induced Formation of Amyloid Beta Oligomers as Revealed by High-Speed AFM            		bioRxiv
            Novel Babesia bovis _ exported proteins that modify properties of
            infected red blood cells            		PLoS Pathogens
            DNA origami demonstrate the unique stimulatory power of single
            pMHCs as T-cell antigens            		Proceedings of the National
            Academy of Sciences
            Structural insights into the mechanism of rhodopsin
            phosphodiesterase            		Nature Communications
            Structural insights into the mechanism of rhodopsin
            phosphodiesterase            		Nature Communications
            High-Speed AFM Reveals Molecular Dynamics of Human Influenza A
            Hemagglutinin and Its Interaction with Exosomes            		Nano Letters
            DNA Ring Motif with Flexible JointsMicromachines
            Nanopores: a versatile tool to study protein dynamicsEssays in Biochemistry
            Geometrical Characterization of Glass Nanopipettes with Sub-10 nm
            Pore Diameter by Transmission Electron Microscopy            		Analytical Chemistry
            Carbon nanotube porin diffusion in mixed composition supported
            lipid bilayers            		Scientific Reports
            One-Step Calibration of AFM in LiquidFrontiers in Physics
            Nanoscale interaction of RecG with mobile fork DNANanoscale Advances
            Convergent evolution of processivity in bacterial and fungal
            cellulases            		Proceedings of the National
            Academy of Sciences
            Convergent evolution of processivity in bacterial and fungal
            cellulases            		Proceedings of the National
            Academy of Sciences of the United States of America
            Interaction of the motor protein SecA and the bacterial protein
            translocation channel SecYEG in the absence of ATP            		Nanoscale Advances
            Nanoreporter of an Enzymatic Suicide Inactivation PathwayNano Letters
            High-speed atomic force microscopy highlights new molecular
            mechanism of daptomycin action            		Nature Communications
            Direct visualization of the conformational change of FUS/TLS upon
            binding to promoter-associated non-coding RNA            		Chemical Communications
            Thermoresponsive Micellar Assembly Constructed from a Hexameric
            Hemoprotein Modified with Poly(N-isopropylacrylamide) toward an Artificial Light-Harvesting System            		Journal of the American
            Chemical Society
            Schizorhodopsins: A family of rhodopsins from Asgard archaea that
            function as light-driven inward H + pumps            		Science Advances
            Two-State Exchange Dynamics in Membrane-Embedded
            Oligosaccharyltransferase Observed in Real-Time by High-Speed AFM            		Journal of Molecular Biology
            Thermoresponsive structural changes of single poly(N-isopropyl
            acrylamide) hydrogel microspheres under densely packed conditions on a solid substrate            		Polymer Journal
            High-Speed Atomic Force Microscopy Reveals Factors Affecting the
            Processivity of Chitinases during Interfacial Enzymatic Hydrolysis of Crystalline Chitin            		ACS Catalysis
            Rad50 zinc hook functions as a constitutive dimerization module
            interchangeable with SMC hinge            		Nature Communications
            Assembly mechanism of a supramolecular MS-ring complex to
            initiate bacterial flagellar biogenesis in vibrio species            		Journal of Bacteriology
            Structural Dynamics of a Protein Domain Relevant to the Water-
            Oxidizing Complex in Photosystem II as Visualized by High-Speed Atomic Force Microscopy            		Journal of Physical Chemistry B
            Recent advances in bioimaging with high-speed atomic force
            microscopy            		Biophysical Reviews
            Dynamic behavior of an artificial protein needle contacting a
            membrane observed by high-speed atomic force microscopy            		Nanoscale
            Enhanced enzymatic activity exerted by a packed assembly of a
            single type of enzyme            		Chemical Science
            High Speed AFM and NanoInfrared Spectroscopy Investigation of A
            β1–42?Peptide?Variants?and?Their?Interaction?With
            POPC/SM/Chol/GM1 Model Membranes            		Frontiers in Molecular
            Biosciences
            The hierarchical assembly of septins revealed by high-speed AFMNature Communications
            Millisecond dynamics of an unlabeled amino acid transporterNature Communications
            Atg9 is a lipid scramblase that mediates autophagosomal membrane
            expansion            		Nature Structural & Molecular
            Biology
            A Simplified Cluster Analysis of Electron Track Structure for
            Estimating Complex DNA Damage Yields            		International Journal of
            Molecular Sciences
            Supramolecular tholos-like architecture constituted by archaeal
            proteins without functional annotation            		Scientific Reports
            Studies on the impellers generating force in muscleBiophysical Reviews
            Diversity of physical properties of bacterial extracellular membrane
            vesicles revealed through atomic force microscopy phase imaging            		Nanoscale
            High-Speed AFM Reveals Molecular Dynamics of Human Influenza A
            Hemagglutinin and Its Interaction with Exosomes            		Nano Letters
            DNA density-dependent uptake of DNA origami-based two-or three-
            dimensional nanostructures by immune cells            		Nanoscale
            Spatiotemporally tracking of nano-biofilaments inside the nuclear
            pore complex core            		Biomaterials
            High-speed atomic force microscopy directly visualizes
            conformational dynamics of the HIV Vif protein in complex with three host proteins            		Journal of Biological Chemistry
            Self-?and?Cross-Seeding?on?α-Synuclein?Fibril?Growth?Kinetics?and
            Structure Observed by High-Speed Atomic Force Microscopy            		ACS Nano
            Liquidity Is a Critical Determinant for Selective Autophagy of Protein
            Condensates            		Molecular Cell
            Capturing transient antibody conformations with DNA origami
            epitopes            		Nature Communications
            Biophysics in Kanazawa UniversityBiophysical Reviews
            Dynamics of oligomer and amyloid fibril formation by yeast prion
            Sup35 observed by high-speed atomic force microscopy            		Proceedings of the National
            Academy of Sciences
            Annexin-V stabilizes membrane defects by inducing lipid phase
            transition            		Nature Communications
            Structure and mechanism of bactericidal mammalian perforin-2, an
            ancient agent of innate immunity            		Science Advances
            Atomic Force Microscopy Visualizes Mobility of Photosynthetic
            Proteins in Grana Thylakoid Membranes            		Biophysical Journal
            Construction of a Hexameric Hemoprotein Sheet and Direct
            Observation of Dynamic Processes of Its Formation            		Chemistry Letters
            Single-molecule imaging analysis reveals the mechanism of a high-
            catalytic-activity mutant of chitinase A from Serratia marcescens            		Journal of Biological Chemistry
            Direct observation and analysis of TET-mediated oxidation
            processes in a DNA origami nanochip            		Nucleic Acids Research
            On-membrane dynamic interplay between anti-GM1 IgG antibodies
            and complement component C1q            		International Journal of
            Molecular Sciences
            Zwitterionic Polypeptides: Chemoenzymatic Synthesis and Loosening
            Function for Cellulose Crystals            		Biomacromolecules



            
                
            
                
                
            
                
                
                
                
            
                
                
                
                
                
            
                    
            
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16青少年男生穿透明内裤照片

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